However, at a low MOI so when azithromycin 5 or 10 µM was coupled with hydroxychloroquine 5 µM, the authors reported that viral replication was inhibited. At a high MOI, they discovered that azithromycin 10 µM combined with hydroxychloroquine 2 µM inhibited viral replication. The authors reported that the concentrations of both drugs found in this study reflected those achieved in lung tissue in vivo; the findings may therefore better reflect what might happen in the human body.
And please, stop emotionally smearing the trials, and stop using words like “poisons”. And if you would like to talk high toxicity, speak to many cancer patients, who’ve to put up with far, far worse, week in week out. It’s worth noting that the Brazil study that was roundly criticized for giving toxic doses of chloroquine to patients never exceeded 1.2 grams each day. You truly don’t appear to value the pharmacodynamics of this drug, and for that reason continually repeating the lie “toxic dose” doesn’t make it less of your lie. The HCQ arm had _lower_ side effects than placebo, which doesn’t tie up very well with your oft quoted lie of “toxic “ doses. I neglect to see how adding zinc or azithromycin will magically make hydroxychloroquine more effective.
Your healthcare provider can determine which drug is more appropriate for you. If you think you have a infection, see your doctor as soon as possible. AZM is known to induce antimicrobial resistance at variable levels in different countries and regions , and antimicrobial resistance is a matter of major concern . Use of AZM and other antibiotics in the management of COVID-19 should be balanced against the risk of AMR.
20 mg/kg/dose PO once weekly as preferred therapy, or alternatively, 5 mg/kg/dose PO once daily. Primary prophylaxis is preferred in infants with a CD4 count significantly less than 750 cells/mm3. Do not discontinue primary prophylaxis for children younger than 2 years. Primary prophylaxis is preferred in children one to two 24 months with a CD4 count significantly less than 500 cells/mm3. Primary prophylaxis is recommended in children 2 to 5 years with a CD4 count significantly less than 75 cells/mm3. Primary prophylaxis may be discontinued after 6 months or more of antiretroviral remedy and a CD4 count more than 200 cells/mm3 for more than 3 consecutive months.
Both cohorts were followed thereafter, with 28-day mortality as the principal endpoint. Raj stresses the value of going for a probiotic supplement during and after taking an antibiotic. “Normally it takes several weeks to get your digestive health back on the right track,” says Raj.